Even better: like LD score regression, MTAG only requires public summary statistics so it may also, like LD score regression, see an explosion in use-since it is usable by everyone & there are so many overlapping phenotypic measurements…)
This illustrates a good way to work around the shortage of high-quality IQ test scores by exploiting multiple more easily-measured phenotypes. “Multi-trait analysis of genome-wide association summary statistics using MTAG”, Turley et al 2018 “A combined analysis of genetically correlated traits identifies 107 loci associated with intelligence”, Hill et al 2017 (use of multiple genetic correlations to overcome measurement error greatly boosts efficiency of IQ GWAS, and provides best public polygenic score to date: 7% of variance.“How Would You Prove You Are a Time-traveler From the Past?”.This is a collation of links and summary of major changes, overlapping with my Changelog brought to you by my donors on Patreon. This is the July 2017 edition of the newsletter previous, June 2017 ( archives).
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